Prostaglandins (biologically active substances)
Mechanism of action of Misoprost-200 (Misoprostol):
Misoprostol is an artificial analogy of prostaglandin E1. The substance affects the gastric mucosa and the smooth muscles of the uterus. The drug has a cytoprotective effect. It increases mucus synthesis in the stomach and enhances the production of NaHCO3 by the gastric mucosa. Due to the direct impact on the parietal layer located in the gastric mucosa.
Misoprostol increases the contraction of the smooth muscles of the myometrium, leading to an expansion of the cervix and an increase in its tone. This improves and facilitates the removal of the contents of the uterine cavity, provoking abortion.
When ingested, the absorption of Misoprostol is carried out quickly. The drug is 85% bound to plasma albumins. The drug is metabolized in the liver and the gastrointestinal tract walls with the participation of misoprostolic acid. The maximum concentration of the substance is fixed after 30-40 minutes. After that, 80-85% of the meaning is excreted by the kidneys, and 15-20% of Misoprostol is released with bile. The half-life is from 20 to 40 minutes. In case of any kidney pathologies, the drug elimination time is doubled.
Indications for Misoprost-200:
Misoprostol is used to prevent the development of peptic ulcer (gastric ulcer), which develops against the background of long-term use of nonsteroidal anti-inflammatory drugs to treat acute gastric ulcers and/or duodenal ulcers. Misoprostol is prescribed in cases of increased risk of ulceration.
Misoprostol is used to terminate pregnancies in the early stages (up to 77 days) combined with Mifepristone.
- diseases of the cardiovascular system, kidneys, and liver associated with prostaglandin dependence;
- individual intolerance;
- bronchial asthma;
- endocrinopathies (diabetes mellitus, adrenal dysfunction, etc.);
- hormone-dependent neoplasms;
- lactation and breastfeeding;
Children and adolescents under 18 years of age are prohibited from taking Misoprostol. In addition, when dehydrating the body, the drug should be taken with extreme caution.
Complications from the gastrointestinal tract can be abdominal pain, increased gas formation (flatulence), dyspepsia (nausea and vomiting), and stool disorders (constipation, diarrhea). Side effects from the reproductive system are painful sensations in the lower abdomen provoked by an active contraction of the middle muscle layer of the uterus, menstrual cycle disorders, and uterine bleeding.
When taking Misoprostol, allergic reactions may occur rash, swelling, itching, etc. In addition, women taking the drug may experience decreased or increased body weight, asthenia, weakness, and fatigue. Convulsive contractions were recorded in isolated cases in women of menopausal age.
Features of interaction with other drugs
Simultaneous administration of nonsteroidal anti-inflammatory drugs and Misoprostol provokes the development of peripheral edema and increased transaminases (ALT, AST). Clinical interaction features with drugs such as Diazepam, Antipyrine, Diclofenac, Aspirin, Piroxicam, Indomethacin, and Naproxen were not observed. Repeated use of Misoprostol slightly increases the concentration of Propranolol in the blood.