Abortive (antigestagenic) drugs.
Mechanism of action of generic RU-486 (Mifepristone)
The steroid drug has a weak androgenic effect and suppresses the development of progesterone by blocking progestogenic receptors. In addition, the drug enhances the contractility of the middle layer of the uterus (myometrium), activates the synthesis and release of a potent anti-inflammatory cytokine (interleukin 8), and increases the sensitivity of the muscle layer to prostaglandins.
As a result, there is a rejection of the decidual (altered mucous membrane of the uterus, formed after embryo implantation) and the removal of the embryo. In addition, the substance inhibits ovulation, changes the endometrium, and blocks implantation of the zygote.
Absorption of Mifepristone at a dosage of 200 mg, when taken per os (orally), occurs quickly. The maximum concentration of the substance in the blood is observed on average 1.3 hours after administration. The duration of the half-life is 18 hours. The drug is 98% bound to plasma albumins and glycoproteins. Oxidative biotransformation of Mifepristone is carried out in the liver. The medicine is excreted mainly with feces (90%) also 10% with urine.
Using of Generic RU486 in Medical Abortion
Generic RU486 is known as the first pill which is used in the interrupt of early pregnancy via Medical Abortion. Medical abortion is a safe and effective method if used till 11 gestation weeks. RU486 contains Mifepristone – an antiprogestagenic drug that blocks the native hormone progesterone.
RU486 spread in many countries in clinics, medical offices, and hospitals, but you can make ordering the Abortion Pill online in our online pharmacy.
The second Pill contains Misoprostol – an analog of prostaglandins and leads to uterine contractions (accompanied by uterine contractions and cramping pain) and blood clot elimination. You can purchase this Abortion Pill on our site.
Ectopiс pregnancy is a contraindication of both Medical and Surgical Abortion.
After 12-14 days after using of Misoprostol, you can make a pregnancy test to determine the absence of pregnancy.
Indications for the use of Generic RU-486:
- Termination of physiological pregnancy in the early stages, namely up to 77 days of amenorrhea;
- Artificial labor excitation for subsequent delivery during full-term pregnancy;
- Conservative preparation before surgical termination of pregnancy in the 1st trimester to soften and open the cervix;
- Artificial labor arousal in intrauterine fetal death in cases of contraindications to the use of oxytocin and prostaglandin;
- Monoclonal benign tumor of the uterus (leiomyoma), the size of which is no more than 12 weeks.
Contraindications to use:
- Pregnancy for more than 77 days;
- Pathological ectopic fertilization;
- Unconfirmed pregnancy.
Common contraindications include:
- Hereditary porphyrin disease;
- Severe bronchial asthma;
- Chronic liver or adrenal insufficiency;
- Individual intolerance to hormonal drugs;
- Severe anemia.
In the presence of inflammatory diseases, eclampsia, severe gestosis, incorrect positions, or large fetal sizes, Mifepristone as an inducer of labor is contraindicated.
Frequent side effects may be dyspeptic disorders (vomiting, nausea), stool disorders, infectious diseases after artificial abortions, uncontrolled contractions, or spasms of the myometrium for several hours. Less common complications include headaches, dizziness, fever, chills, decreased blood pressure, Quincke’s edema, allergic skin rashes, and uterine bleeding. In addition, cases of the lethal shock of an infectious-toxic nature and uterine ruptures during labor induction were recorded.
Features of interaction with other drugs
Specific studies of the interaction of Mifepristone with other drugs have not been performed. But it is known that the antibiotic Rifampicin, the hormonal drug Dexamethasone, and some anticonvulsants (Carbamazepine and Phenobarbital) can reduce the content of Mifepristone in the blood serum. Antifungal drugs such as Itraconazole and Ketoconazole and the antibiotic Erythromycin, on the contrary, increase the concentration of the drug in the blood.
Where can I get generic RU486?
Our website allows you to buy Generic RU-486 online. To ensure that our customers have a successful Medical Abortion at home without needing surgery, we strive to give the most satisfactory services possible.
What is the price of the Generic RU486 tablet in dollars?
The price of RU-486 on our website is reasonable, and you can quickly purchase it and have it delivered to your home or workplace. We also provide services such as expedited delivery, overnight shipping, and various additional options to make the purchasing experience as simple as possible.
What is the best place to get the Generic RU486 kit?
Purchasing an RU-486 kit on the internet is convenient and straightforward. Purchase Generic RU-486 from our website, which is available 24/7. All the items we sell have been authorized by the FDA and are of high quality. In addition, we safeguard your online privacy with our data and transaction security system and protect your offline privacy with our discrete packaging.