Combipack Mifepristone 200 mg + Misoprostol 800 mcg

Product description

Combipack Mifepristone + Misoprostol — The Complete Product Guide

Abortion is a sensitive and deeply personal decision for many individuals. When considering an abortion, it is crucial to have access to accurate information about the process and available options. One common method of terminating an early pregnancy is through the use of Abortion Pills. In this article, we will provide a comprehensive guide to Abortion Pill kits, including what they are, how they work, potential risks and side effects, and when to seek medical assistance.

Our online pharmacy has other Abortion Pill kits in stock that contain identical doses of Mifepristone and Misoprostol: MTP kit, Abortion Pills Kit, and Mifepristone + Misoprostol Kit.

Understanding Combipack Mifepristone + Misoprostol:

Combipack Mifepristone + Misoprostol, also known as Medical Abortion or Medication Abortion, involves a combination of two medications — Mifepristone and Misoprostol. These pills are generally used to terminate pregnancies up to 10 weeks gestation, although the exact timeframe may vary depending on local regulations and healthcare provider recommendations.

1. Mifepristone (RU-486): This pill is taken first and works by blocking the hormone progesterone, which is necessary for maintaining a pregnancy. Without progesterone, the lining of the uterus breaks down, preventing the pregnancy from progressing.
2. Misoprostol: Taken within 24–48 hours after Mifepristone, Misoprostol causes the uterus to contract, expelling the pregnancy. This process typically resembles a heavy menstrual period, often accompanied by cramping and bleeding.

Understanding Mifepristone 200 mg

Mifepristone tablet, also known as the Abortion Pill or RU-486, is a medication used to terminate early pregnancies up to 77 days (11 gestational weeks) after the first day of a woman’s last menstrual period (LMP). It is a synthetic steroid that works by blocking the hormone progesterone, which is needed for a pregnancy to continue.

Pharmacodynamics

Mifepristone tablet, a synthetic steroid, is used for medically terminating intrauterine pregnancy up to 77 days’ gestation due to its anti-progestational effects. It has been demonstrated that doses equal to or exceeding 1 mg/kg of Mifepristone can counteract the effects of progesterone on the endometrium and myometrium in women.

Additionally, during pregnancy, this compound sensitizes the myometrium to the contraction-stimulating actions of prostaglandins. Mifepristone also possesses anti-glucocorticoid and weak antiandrogenic properties.

Research has shown that doses ranging from 10 to 25 mg/kg of Mifepristone can inhibit the activity of the glucocorticoid dexamethasone in rats. In human subjects, doses equal to or exceeding 4.5 mg/kg lead to a compensatory increase in adrenocorticotropic hormone (ACTH) and cortisol levels.

Uses of Mifepristone:

1. Medical Termination of Pregnancy (Abortion): Mifepristone is used in combination with another medication called Misoprostol to induce a non-surgical abortion. It is a safe and effective option for ending early pregnancies in the privacy of one’s home.

2. Cushing’s Syndrome: Mifepristone can also be prescribed to manage the symptoms of Cushing’s syndrome, a hormonal disorder characterized by high levels of cortisol in the body.

How Mifepristone Works:

Mifepristone’s anti-progestational effects stem from its competitive binding with progesterone at progesterone-receptor sites. Research conducted with different oral doses across multiple animal species (including mice, rats, rabbits, and monkeys) indicates that the compound hinders the function of endogenous or exogenous progesterone.

This leads to the breakdown of the uterine lining and the detachment of the embryo from the uterine wall. When followed by Misoprostol, which causes uterine contractions, the pregnancy is expelled from the uterus.

When used to manage Cushing’s syndrome, Mifepristone disrupts the attachment of cortisol to its receptor. While it does not lower cortisol production, it diminishes the impact of surplus cortisol, such as elevated blood sugar levels.

Toxicity

Almost all women who take Mifepristone are likely to experience adverse effects, with many experiencing multiple reactions. Approximately 90% of patients report adverse effects after receiving Misoprostol on the third day of the treatment regimen. Common side effects encompass heavier bleeding compared to a typical menstrual period, abdominal discomfort, uterine cramps, nausea, vomiting, and diarrhea.

Food Interactions

Avoid grapefruit products. Grapefruit inhibits the metabolism of Mifepristone through the CYP3A4 pathway, causing increased serum levels of Mifepristone.

Take it with food. Taking Mifepristone with meals has been shown to increase serum levels of Mifepristone.

Side Effects of Mifepristone:

Common side effects of Mifepristone may include:

• Nausea and vomiting;
• Abdominal cramping;
• Vaginal bleeding;
• Fatigue;
• Headache;
• Dizziness.

It is essential to note that side effects may vary from person to person, and not everyone will experience all of these symptoms. Serious complications are rare but can include heavy bleeding, infection, or incomplete abortion.

Considerations Before Taking Mifepristone:

Before taking Mifepristone, it is essential to consider the following:

1. Pregnancy Gestation: Mifepristone is only recommended for ending early pregnancies up to 70 days gestation. Beyond this timeframe, other options may be considered.
2. Medical History: It is crucial to inform your healthcare provider about any health conditions, allergies, or medications you are currently taking before using Mifepristone.
3. Follow-up Care: After taking Mifepristone, follow-up care is essential to ensure the completion of the abortion and address any concerns or complications that may arise.

When to Seek Medical Help:

While Mifepristone is considered safe and effective for most women, it is essential to seek medical help if you experience any of the following symptoms after taking the medication:

• Severe abdominal pain or cramping;
• Heavy bleeding that soaks more than two pads per hour for two hours in a row;
• Fever or chills;
• Foul-smelling vaginal discharge

Understanding Misoprostol

Misoprostol is a medication commonly used in combination with Mifepristone for Medical Abortion, as well as for preventing stomach ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs) like aspirin and ibuprofen. It is a prostaglandin analog that helps soften the cervix and cause uterine contractions. Understanding the uses, effects, and considerations of Misoprostol is essential for those considering its use.

Uses of Misoprostol:

1. Medical Termination of Pregnancy (Abortion): Misoprostol is often used in combination with Mifepristone to induce a Medication Abortion. It helps to expel the contents of the uterus by causing contractions.

2. Prevention of Stomach Ulcers: Misoprostol can also be prescribed to protect the stomach lining and prevent gastric ulcers, but not duodenal ulcers in individuals taking NSAIDs for conditions like arthritis. Misoprostol is indicated as a tablet to reduce the risk of NSAID-induced in high-risk patients. Misoprostol is also formulated in combination with diclofenac to treat symptoms of osteoarthritis or rheumatoid arthritis in patients with a high risk of developing gastric ulcers.

How Misoprostol Works:

Misoprostol works by binding to specific receptors in the uterus, which leads to cervical softening and uterine contractions. This process helps to expel the pregnancy tissue during a Medical Abortion, and can also protect the stomach lining by increasing mucus production and reducing acid secretion.

Pharmacodynamics

Misoprostol is a prostaglandin E1 analog used to reduce the risk of NSAID-induced gastric ulcers by reducing the secretion of gastric acid from parietal cells. Misoprostol is also used to manage miscarriages and is used alone or in combination with Mifepristone for first-trimester abortions.

An oral dose of Misoprostol has an 8-minute onset of action and a duration of action of approximately 2 hours.

A sublingual dose has an 11-minute onset of action and a duration of action of approximately 3 hours.

A vaginal dose has a 20-minute onset of action and a duration of action of approximately 4 hours.

A rectal dose has a 100-minute onset of action and a duration of action of approximately 4 hours.

Clearance

Because of the rapid de-esterification of Misoprostol before or during absorption, it is usually undetectable in plasma. Misoprostol’s active metabolite, Misoprostol acid, has a total body clearance of 0.286L/kg/min.

Subjects with mild renal impairment had a total body clearance of 0.226±0.073L/kg/min. Subjects with moderate renal impairment had a total body clearance of 0.270±0.103L/kg/min, and subjects with end-stage renal disease had a total body clearance of 0.105±0.052L/kg/min.

Toxicity

The oral LD₅₀ in rats is 81 mg/kg and in mice is 27 mg/kg. The intraperitoneal LD₅₀ in rats is 40 mg/kg and in mice is 70 mg/kg.

Patients experiencing an overdose may present with sedation, tremor, convulsions, dyspnea, abdominal pain, diarrhea, fever, palpitations, hypotension, and bradycardia. Hemodialysis is not expected to be useful in the treatment of Misoprostol overdose but oral activated charcoal may help reduce absorption. In the event of an overdose, treat symptoms with supportive therapy.

This may include the removal of undissolved tablets from the vagina or buccal cavity, intravenous fluid replacement, acetaminophen, diazepam, haloperidol, or intramuscular diclofenac depending on the symptoms that present.

Food Interactions

Take it with food. Food decreases the incidence of diarrhea.

Side Effects of Misoprostol:

Common side effects of Misoprostol may include:

• Abdominal cramping;
• Vaginal bleeding;
• Nausea and diarrhea;
• Chills or fever;
• Headache;
• Dizziness.

As with any medication, individual reactions may vary, and not everyone will experience all of these side effects. Serious complications are rare but can include heavy bleeding, infection, or incomplete abortion.

Considerations Before Taking Misoprostol:

Before using Misoprostol, it is important to consider the following factors:

1. Medical History: Inform your healthcare provider about any medical conditions, allergies, or medications you are currently taking, as they may affect the safety and effectiveness of Misoprostol.

2. Pregnancy Termination: Misoprostol is typically used in combination with Mifepristone for Medical Abortion in the early stages of pregnancy. Follow the prescribed regimen and seek medical advice if you have any concerns.

3. Stomach Ulcer Prevention: If using Misoprostol for stomach ulcer prevention, follow your healthcare provider’s instructions carefully and report any unusual symptoms or side effects.

When to Seek Medical Help:

While Misoprostol is generally safe for most individuals, it is important to seek medical help if you experience any of the following symptoms after taking the medication:

• Severe abdominal pain or cramping;
• Heavy bleeding that persists or worsens;
• Signs of infection, such as fever or chills;
• Persistent nausea, vomiting, or diarrhea.

Using a Combipack Mifepristone + Misoprostol:

An Abortion Pill kit usually contains both Mifepristone and Misoprostol. It is important to note that these medications should only be obtained legally through a healthcare provider or a trusted pharmacy. Self-administration of Abortion Pills without medical supervision is highly discouraged due to potential risks and complications.

1. Medical Consultation: Before considering an Abortion Pills kit, it is crucial to consult a qualified healthcare professional to create an evaluation and mitigation strategy. The same patient agreement form should be filled out. They can provide necessary information about the procedure, perform an ultrasound to determine the gestational age, and discuss potential risks and alternatives. Medication Guide for Abortion Pills.
2. Administration and Follow-up: If a healthcare provider determines that Medication Abortion is appropriate, they will provide the necessary instructions for taking the pills. It is essential to strictly follow the prescribed dosage and timing. After taking the medication, individuals should schedule a follow-up appointment to ensure that the abortion is complete and to address any concerns or complications.

Potential Risks and Side Effects:

While Medical Abortion is generally considered safe, there are potential risks and side effects to be aware of. These may include:

1. Heavy bleeding: It is normal to experience heavy bleeding and cramping during and after the abortion process. However, prolonged and excessively heavy bleeding may indicate a complication and should be reported to the healthcare provider immediately.
2. Incomplete abortion: In some cases, the abortion may be incomplete, requiring further medical intervention such as a surgical procedure to remove any remaining pregnancy tissue.
3. Infection: Although rare, infections can occur following an abortion. Symptoms such as fever, persistent pain, and foul-smelling discharge should be promptly reported to a healthcare professional.

Abortion Pills and Ectopic Pregnancy

An ectopic pregnancy occurs when a fertilized egg implants itself outside the uterus, usually in the fallopian tubes. This can be a life-threatening condition if left untreated, as the growing embryo can cause the fallopian tube to rupture, leading to internal bleeding and potentially serious complications.

When it comes to ectopic pregnancy, Abortion Pills such as Mifepristone and Misoprostol are not recommended, as they are designed to terminate pregnancies within the uterus. In the case of an ectopic pregnancy, surgical intervention is typically necessary to remove the embryo and prevent further complications.

Women must be aware of the symptoms of an ectopic pregnancy, which may include abdominal pain, vaginal bleeding, shoulder pain, and dizziness. If you suspect you may have an ectopic pregnancy, it is important to seek immediate medical attention to prevent any serious health risks.

When to Seek Medical Assistance:

It is crucial to monitor your symptoms and seek medical assistance if:

• Heavy bleeding persists for longer than expected (soaking through more than two pads per hour);
• Severe pain or cramping does not improve with pain medication;
• You have a fever over 100.4 °F (38 °C);
• Ongoing and heavy bleeding and/or cramping persists for more than a week.

Conclusion:

An Abortion Pills kit can be a safe and effective method of terminating an early pregnancy when used under medical supervision. However, it is essential to consult a healthcare professional before considering this option. Only a qualified healthcare provider can provide personalized advice and guidance tailored to your specific circumstances.