Abortive (antigestagenic) drugs.
Mechanism of action of Mifepristone
This steroid drug has a modest androgenic effect and inhibits progestogenic receptors, resulting in decreased progesterone synthesis. The medication also boosts the muscle layer’s sensitivity to prostaglandins, promotes the production and release of a potent anti-inflammatory cytokine (interleukin 8), and raises the contractility of the uterus’s middle layer (the myometrium).
When embryo implantation is rejected, and the embryo is evacuated, the uterine mucous membrane changes. The chemical also inhibits ovulation, changes the endometrium, and hinders zygote implantation.
Mifepristone is quickly absorbed once 200 mg are administered orally (orally). The medicine reaches its maximal concentration in the blood after an average of 1.3 hours.
The half-life is about 18 hours. Almost all medications are bound to proteins in the blood, namely albumins and glycoproteins. The liver controls mifepristone’s oxidative biotransformation. Most of the medication is excreted via feces, with 10% eliminated through urine.
Indications for the use of Mifepristone:
- Medical termination of a physiological pregnancy as early as possible, up to 77 days of amenorrhea (in combination with Misoprostol);
Inducing labor artificially to facilitate a successful delivery at term;
- Preparing the cervix conservatively for a surgical abortion in the first trimester to soften and open it;
- In the event of intrauterine fetal mortality, inducing labor artificially when oxytocin and prostaglandin usage is contraindicated;
- Leiomyoma is a benign, monoclonal uterus tumor that often doesn’t grow more significant than 12 weeks.
Contraindications to use:
- Pregnancy for more than 77 days;
- Pathological ectopic fertilization;
- Unconfirmed pregnancy.
Common contraindications include:
- Hereditary porphyrin disease;
- Severe bronchial asthma;
- Chronic liver or adrenal insufficiency;
- Individual intolerance to hormonal drugs;
- Severe anemia.
In the presence of inflammatory diseases, eclampsia, severe gestosis, incorrect positions, or large fetal sizes, Mifepristone as an inducer of labor is contraindicated.
- Abdominal pain;
- Severe allergic reaction (anaphylaxis);
- Abnormal heartbeat;
- Chest pain;
- Gas (flatulence);
- Gastrointestinal bleeding;
- Hearing loss;
- Heart attack (myocardial infarction);
- Rupture of the uterus;
- Blood clot.
Features of interaction with other drugs
Mifepristone’s potential medication interactions have not been studied in detail. In contrast, the antibiotic Rifampicin, the hormone medication Dexamethasone, and a few anticonvulsants (Carbamazepine and Phenobarbital) are known to lower Mifepristone levels in the blood serum. In contrast, the blood concentration of antifungal medications like Itraconazole and Ketoconazole and the antibiotic Erythromycin increases.
Where can I get Mifepristone?
We provide an online store where you may get Mifepristone and other abortion drugs. We make every effort to ensure that our customers have a great experience with their Medical Abortion at Home without needing surgery.
What is the price of the Mifepristone tablet in dollars?
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